Cimetidine is an H2 receptor antagonist - Saab General Bulletin Board - Saabnet.com
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Cimetidine is an H2 receptor antagonist
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Posted by AdamB [Email] (#3) [Profile/Gallery] (more from AdamB) on Tue, 12 Apr 2005 09:50:12 Share Post by Email
In Reply to: Another of Dean's health related posts, Dean, Tue, 12 Apr 2005 08:51:13
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It's use in gastric/duodenal ulcers and heartburn is based on it's antagonistic effect on H2 receptors on the parietal cells. This reduces their secretion of stomach acid.

There are H2 receptors many places in the body and with very different effects. For example a kind of lymphocyte has them, and the theory goes that the effects mentioned by Dean is related to these cells.

However, as with practically all medicine there are some RARE side effects with cimetidine:
gynaecomastia in men (growth of breasts), diarrhoea, dizziness, muscle pains, transient rashes, confusion in the elderly and very rarely reduced liver function.

An important fact to remember about cimetidine is that it retards the metabolism of various drugs by inhibiting cytochrome P450 enzymes. This means that a range of drugs including oral anticoagulants and tricyclic antidepressants have prolonged half lives in the body and can thereby have higher concentrations than expected/wanted and it can become dangerous if you're taking one of these drugs together with cimetidine.

When you contemplate taking a drug, it's always a balancing act of the benefits vs. the risk and severity of unwanted side effects. I'm not trying to scare anybody from taking cimetidine because it is a pretty safe drug. Just take it into consideration. For example I'd probably not take cimetidine for a small uncomplicated HPV infection (a wart or two).

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