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Re: Some sceptiscism is good, but remember to Posted by AdamB [Email]  (#3)  [Profile/Gallery]
(more from AdamB) on Tue, 3 Aug 2004 09:20:42
In Reply to: Re: Some sceptiscism is good, but remember to, Dean, Mon, 2 Aug 2004 21:24:51 Members do not see ads below this line. - Help Keep This Site Online - Signup |
"Do those books talk about the affects of CoQ10 which gets lowered by the statin drugs?"
Yes ubiquinone, which is what we call it, is very well described in various medical books. It's an essential part (it's an electron carrier) of the respiratory chain in the mitochondria. However I have seen no evidence that statins should have a significant influence on ubiquinone levels? I'd be very interested in it though. Since it appears that no side effects are associated with ubiquinone/CoQ10 intake, I guess it can't harm to take them with statins if it makes you feel safer.
When you give statins to patients, you check the serum level of aminotransferase (liver enzyme) before and during treatment. Muscle pain is associated with increased creatine kinase levels which are also measured before and during treatment. All the guidelines says to discontinue use or lower dose, if these are raised (there are specific boundaries). It's when treatment is continued with same dose that you encounter the danger of rhabdomyolysis. That some doctors apparently don't follow the guidelines is very unfortunate, but it doesn't make statins bad.
Also there are some contra indications to HMG-CoA reductase inhibitor therapy that should be followed: Liver disease, pregnancy, lactation, alchoholism etc. When you follow these, adverse effects are minimised.
I mentioned the 4S-study. Here are 2 others:
West of Scotland Coronary Prevention Study (WOSCOPS):
6500 45- to 64-year old healthy men were randomised to placebo or pravastatin. The group with statin had a reduced overall mortality of 22% and 31% lower risk of heart attack or death from coronary disease.
The Cholesterol and Recurrent Events (CARE) Trial:
>4000 patients who had recovered from myocardial infarction and in whom plasma cholesterol was <6.2 mmol/l were allocated to treatment with placebo or pravastatin. Pravastatin lowered LDL-cholesterol by 28%, the risk of either death from coronary disease or recurrent myocardial infarction by 24% and the risk of stroke by 31%.
There are many other studies regarding statins, but as I said, I haven't seen a single one showing anything else than statins to be very safe drugs when you follow the guidelines.
"The great thing about folks reading on the internet, or a nice medical book, it that they are paying attention to things instead of been sheep. And healthy debate is a wonderful thing."
Yes I agree 100%. But it's a problem when people become scared of very rare adverse effects, and then stop taking the drugs they need. Thus trading a tiny risk for a big one.
posted by 194.255.11...
West of Scotland Coronary Prevention Study
, Mon, 2 Aug 2004 16:14:17, Tue, 3 Aug 2004 08:08:37, Tue, 3 Aug 2004 15:06:09, Tue, 3 Aug 2004 16:01:32, Tue, 3 Aug 2004 09:20:42 <-- Viewing This Message, Tue, 3 Aug 2004 15:54:44, Tue, 3 Aug 2004 15:41:09, Tue, 3 Aug 2004 15:42:31, Tue, 3 Aug 2004 16:03:40, Mon, 2 Aug 2004 16:18:48
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